Authors:Hisham K. Hamadeh, Cynthia A. Afshari,
Publisher: Wiley-Liss
Keywords: applications, principles, toxicogenomics
Number of Pages: 361
Published: 2004-09-06
List price: $109.95
ISBN-10: 0471434175
ISBN-13: 9780471434177

With the sequencing of human and other genomes completed, the new field of toxicogenomics is now emerging into the realm of practice. This field brings together many different disciplines to incorporate current genomics knowledge into traditional toxicology. By finding more precise ways to measure the response of living systems and environments to chemical exposures, toxicogenomics promises to greatly alter and improve the drug development process, to name just one area of application. Toxicogenomics: Principles and Applications provides a unified, thorough text on key breakthrough technolog

Author: Christer Hogstrand
Publisher: Elsevier Science
Keywords: experimental, biology, advances, volume, toxicogenomics, comparative
Number of Pages: 352
Published: 2008-08-12
List price: $110.00
ISBN-10: 0444532749
ISBN-13: 9780444532749

Toxicogenomics analyses the activity of a particular toxin or chemical substance on living tissue based upon a profiling of its known effects on genetic material. Toxicogenomics is important because it may enhance understanding of mechanisms of toxicity, cellular defence systems, and drug action. If this technique is proven to work, it could be used in a similar way for toxicology and toxin-determination to DNA-testing in the forensic identification of individuals. Comparative Toxicogenomics provides a timely overview of current achievements and future areas of development including a review o

Author: J?rgen Borlak
Publisher: Wiley-VCH
Keywords: research, applications, current, view, toxicogenomics, strategic, handbook
Number of Pages: 705
Published: 2005-03-28
List price: $325.00
ISBN-10: 3527303421
ISBN-13: 9783527303427

Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies.The authors work for major research institutions, such as the

Author: Czech Republic) NATO Advanced Research Workshop on
Publisher: IOS Pre
Keywords: asi, nato, proteomics, toxicogenomics
Number of Pages: 216
Published: 2004-05-01
List price: $168.00
ISBN-10: 1586034022
ISBN-13: 9781586034023

The field of toxicology has developed a well-characterized set of techniques to assess the behavioral and histopathological consequences of exposure to environmental insults using a number of animal models. These techniques are suitable for determining crude endpoints of exposure such as death, but are not optimal for assessing the more subtle effects of very low level or multi-agent chemical exposures, nor do they offer mechanistic explanations at the molecular level. This book is designed to have a mix of chapters devoted to classical toxicology followed by those focused more on the emerging