Authors:Diana Anderson, Martin H. Brinkworth,
Publisher: Royal Society of Chemistry
Keywords: issues, toxicology, toxicity, developmental, mediated, male
Number of Pages: 305
Published: 2007-05-01
List price: $179.00
ISBN-10: 0854048472
ISBN-13: 9780854048472
The issue of male germ line mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile over recent years. Mutations are thought to be becoming more prevalent as a result of: exposure to chemicals in the environment; anti cancer regimes that use genotoxic agents and assisted conception techniques. In addition to the increasing frequency of mutations in the general population, attention is also being given to the effects of epigenetic events on future generations. "Male-mediated Developmental Toxicity" discusses these issues comprehensively a
Author: Challa S. S. R. Kumar
Publisher: Wiley-VCH
Keywords: nanotechnologies, life, sciences, issues, environmental, toxicity, health, nanomaterials
Number of Pages: 351
Published: 2006-08-30
List price: $210.00
ISBN-10: 3527313850
ISBN-13: 9783527313853
Offering a unique overview of nanoparticle-related environmental risks depending on particle type and exposed surroundings, this volume brings together both medical and nanotechnological aspects. The book adopts an in-depth approach to toxicology from both particle size as well as particle nature, covering all important nanomaterial classes: carbon materials, polymers, metals, and metal oxides. Clearly structured, the text is careful to address the effects on human physiology, air, water and the general environment.
Authors:Edward Kerns, Li Di,
Publisher: Academic Pre
Keywords: adme, toxicity, optimization, methods, design, properties, concepts, structure, drug
Number of Pages: 552
Published: 2008-02-19
List price: $99.95
ISBN-10: 0123695201
ISBN-13: 9780123695208
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for,
Author: US Dept. of Labor
Publisher: William Andrew
Keywords: economic, technological, data, toxicity, health, regulated, hazardous, substances, osha
Number of Pages: 2326
Published: 1991-01-14
List price: $270.00
ISBN-10: 0815512406
ISBN-13: 9780815512400
These two volumes provide industrial exposure data on over 650 substances currently regulated, or candidates for regulation, by OSHA. Information included on each substance, as available: synonyms, trade names, physical description, health effects, toxicity/exposure limits, industry use data, NIOSH Exposure Survey data, NIOSH Occupational Hazard Survey data, OSHA Exposure data, engineering controls, personal protective equipment, and storage.
Author: Peter Greaves
Publisher: Elsevier Science
Keywords: relevance, drug, safety, evaluation, interpretation, third, preclinical, toxicity, studies, histopathology
Number of Pages: 960
Published: 2007-04-06
List price: $170.00
ISBN-10: 0444527710
ISBN-13: 9780444527714
This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight a
Authors:Michael S. Roberts, Kenneth A. Walter,
Publisher: Informa HealthCare
Keywords: drugs, pharmaceutical, sciences, second, assessment, absorption, toxicity, dermal
Number of Pages: 600
Published: 2007-12-14
List price: $299.95
ISBN-10: 0849375916
ISBN-13: 9780849375910
The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new
Authors:Daniel Schlenk, William H. Benso,
Publisher: CRC
Keywords: teleosts, volume, organs, freshwater, marine, organ, toxicity, target
Number of Pages: 384
Published: 2001-06-01
List price: $154.95
ISBN-10: 0415248388
ISBN-13: 9780415248389
A collection of research on specific target organs of marine and freshwater teleosts, describing how various environmentally-acquired toxic agents disrupt the normal physiological processes.
