Author: Gerald Litwack
Publisher: Humana Press
Keywords: hormones, purification, receptor, others, water, balancing, steroid, volume, receptors, thyroid
Number of Pages: 430
Published: 1990-10-30
List price: $164.50
ISBN-10: 0896031837
ISBN-13: 9780896031838
Receptor Purification is a unique, practical two-volume guide to the purification of most receptor types, including receptors for neurotransmitters, polypeptide hormones, steroid hormones, and a variety of other ligands involved in many biological processes. Today’s methods of receptor purification have evolved from years of research on the mechanisms of receptor actions, where they were needed to discover receptor properties and ultimately for use in cloning. Receptor Purification provides a comprehensive source of techniques to enable the purification of cloned receptors, as well a
Author: GREENSTEIN
Publisher: Informa Healthcare
Keywords: methods, research, receptor
Number of Pages: 342
Published: 1995-08-01
List price: $200.00
ISBN-10: 3718656701
ISBN-13: 9783718656707
Receptor Research Methods has been designed with the "systems" worker in mind. The emphasis is on how receptors can be used to tackle a problem, rather than studying the receptor per se.This book describes and evaluates the techniques used in receptor research. The range and scope of receptor studies becomes apparent through giving examples of the use of these techniques in overcoming problems of receptor identification in the brain and other tissues. Measurement of receptor action is done directly and also indirectly, through cellular expression of receptor activation by appropriate ligands.
Author: Hao Wu
Publisher: Springer
Keywords: experimental, medicine, biology, advances, factors, receptor, associated, tnf
Number of Pages: 225
Published: 2007-06-25
List price: $149.00
ISBN-10: 0387706291
ISBN-13: 9780387706290
It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease,
Author: Min Li
Publisher: Humana Press
Keywords: molecular, biology, methods, protocols, receptor, nmda
Number of Pages: 208
Published: 1999-04-01
List price: $115.00
ISBN-10: 0896037134
ISBN-13: 9780896037137
Min Li and a panel of hands-on experimentalists detail state-of-the-art molecular techniques for studying NMDA ligand-gated ion channels and developing assays for nontherapeutic lead selection. The topics range from cDNA cloning to in vitro and in vivo investigation of the channel complex in the mammalian brain. Additional topics include the biochemical analysis of the channel protein and the construction of various heterologous systems for both basic research and high throughput screens (HTS) for pharmaceutical chemicals. Although the focus is on NMDA receptors, the methods are applicable to
Author: Irwing M. Klotz
Publisher: Wiley
Keywords: perplexed, guide, energetics, receptor, ligand
Number of Pages: 192
Published: 1997-03-14
List price: $99.95
ISBN-10: 0471176265
ISBN-13: 9780471176268
A foundation for quantitative perspectives and a framework for interpreting experimental observations. Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantitie
Author: Michael W. Quick
Publisher: Wiley-Liss
Keywords: methodology, biochemistry, receptor, transporters, transmembrane
Number of Pages: 316
Published: 2002-09-09
List price: $210.00
ISBN-10: 0471065137
ISBN-13: 9780471065135
A must-have far-reaching text that provides readers with a state-of-the-art molecule update on transmembrane transporters, focusing on the methodological approaches currently employed to better understand how transporters work and how they can be used in cutting edge therapies. Each chapter begins with an overview of the importnat biological questions presently being considered in their field, then presents scientific approaches to address these questions. In explaining approaches, the authors cover bench-top protocols, conceptual frameworks, data obtained, and pitfalls common to the technique
Authors:I. Yamamoto, J.E. Casida,
Publisher: Springer
Keywords: receptor, acetylcholine, nicotinic, insecticides, nicotinoid
Number of Pages: 300
Published: 1999-09-15
List price: $282.00
ISBN-10: 443170213X
ISBN-13: 9784431702139
The nicotinoids are the most important new class of pesticides, joining the organophosphorus compounds, methylcarbamates, and pyrethroids as the major insecticides. Recently, imidacloprid and related nicotinoids have begun replacing organophosphorus and methylcarbamate compounds as insecticides to control insect pests on major crops. Nicotinoids act on the nicotinic acetylcholine receptor, as does naturally occurring nicotine, but with remarkable effectiveness against insects while being safe for mammals; they are quickly degraded and do not persist in the environment. This volume describes th
