Author: Bridgette V. Doupher
Publisher: Nova Science Publishers
Keywords: research, new, prions
Number of Pages: 311
Published: 2006-08-03
List price: $210.00
ISBN-10: 1600210198
ISBN-13: 9781600210198

Prions are disease-causing agents that are neither bacterial nor fungal nor viral and contain no genetic material. A prion is a protein that occurs normally in a harmless form. By folding into an aberrant shape, the normal prion turns into a rogue agent. It then co-opts other normal prions to become rogue prions. Prions have been held responsible for a number of degenerative brain diseases, including scrapie (a fatal disease of sheep and goats), mad cow disease, Creutzfeldt-Jacob disease, fatal familial insomnia, kuru, an unusual form of hereditary dementia known as Gertsmann-Straeussler-Schei

Author: Claudio Soto
Publisher: CRC Press
Keywords: proteins, biology, new, prions
Number of Pages: 184
Published: 2005-12-20
List price: $162.95
ISBN-10: 0849314429
ISBN-13: 9780849314421

The current interest in prion diseases has been fueled by the panic that originated from the appearance of a new variant of Creutzfeldt-Jakob disease and the evidence linking it to human exposure to the bovine spongiform encephalopathy (BSE) agent. Peer-reviewed to assure accuracy, this book describes the science, concepts, hypothesis, and mechanisms of prion disease transmission. It covers human and animal prion diseases, their incidence, prevalence, origin, and clinical and neuropathologic characteristics. The author provides scientific facts and a clear explanation of the relevance and impl

Authors:Brian K. Nunnally, Ira S. Krull,
Publisher: CRC Press
Keywords: disease, cow, mad, prions
Number of Pages: 413
Published: 2003-10-17
List price: $219.95
ISBN-10: 0824740831
ISBN-13: 9780824740832

Recommends possible strategies to prevent bovine spongiform encephalopathy from spreading. Considers cyclic amplification of scrapie prion protein and its implications for diagnosis, as well as the sensitive detection of prion proteins by immunoassay. Discusses prion detection techniques and their application to ensure the safety of biological products.

Author: Beat Hoernlimann; Detlev Riesner; et al.
Publisher: Walter de Gruyter
Keywords: animals, humans, prions
Number of Pages: 714
Published: 2006-12-01
List price: $147.00
ISBN-10: 3110182750
ISBN-13: 9783110182750

This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A detailed presentation of the impact of prion diseases in fields such as pharmaceutics, blood products, disinfec

Authors:Ronald Wetzel, Indu Kheterpal,
Publisher: Academic Press
Keywords: volume, methods, enzymology, part, aggregates, prions, protein, amyloid
Number of Pages: 430
Published: 2006-10-20
List price: $182.00
ISBN-10: 0121828174
ISBN-13: 9780121828172

The ability of polypeptides to form alternatively folded, polymeric structures such as amyloids and related aggregates is being increasingly recognized as a major new frontier in protein research. This new volume of Methods in Enzymology along with Part C (volume 413) on Amyloid, Prions and other Protein Aggregates continue in the tradition of the first volume (309) in containing detailed protocols and methodological insights, provided by leaders in the field, into the latest methods for investigating the structures, mechanisms of formation, and biological activities of this important class of