Author: G. I. Bryne
Publisher: CRC Press
Keywords: immunology, pathogens, nonviral, interferon
Number of Pages: 336
Published: 1988-07-29
List price: $199.95
ISBN-10: 0824779738
ISBN-13: 9780824779733

Authors:Mien-Chie Hung, Leaf Huang, Ernst Wagner,
Publisher: Academic Press
Keywords: therapy, gene, vectors, nonviral
Number of Pages: 456
Published: 1999-06-21
List price: $142.00
ISBN-10: 0123584655
ISBN-13: 9780123584656

Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients’ cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways.Thus, research was undertaken to find a safer way to transfer genes to

Authors:Leaf Huang, Mien-Chie Hung, Ernst Wagner,
Publisher: Academic Press
Keywords: second, advances, genetics, volume, part, vectors, gene, therapy, nonviral
Number of Pages: 400
Published: 2005-07-21
List price: $139.95
ISBN-10: 0120176548
ISBN-13: 9780120176540

The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therap

Author: Mark A. Findeis
Publisher: Humana Press
Keywords: methods, molecular, medicine, biology, protocols, nonviral, gene, therapy, vectors
Number of Pages: 416
Published: 2001-08-09
List price: $144.00
ISBN-10: 0896037126
ISBN-13: 9780896037120

Mark A. Findeis and a panel of active researchers present their best methods not only for preparing, handling, and characterizing gene delivery agents, but also for gene delivery. To help those preparing and characterizing gene transfer agents, the contributors examine a broad range of compounds that bind with DNA to form the compact condensed phases that facilitate cellular delivery-among them peptide conjugates, synthetic polymers, and lipids. They also outline specific approaches to gene transfer in vivo, including direct delivery by intratumoral injection and indirect delivery by