Authors:G. Ali Qureshi, S. Hasan Parvez,
Publisher: Elsevier Science
Keywords: disorders, neurodegenerative, stress, oxidative
Number of Pages: 794
Published: 2007-06-07
List price: $192.00
ISBN-10: 0444528091
ISBN-13: 9780444528094

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This

Authors:Able Lajtha, Allen Honeyman, Lynda J. Katz, Mauro Ben
Publisher: Springer
Keywords: diseases, neurodegenerative, pathophysiology, proteases, role
Number of Pages: 302
Published: 2001-07-31
List price: $119.00
ISBN-10: 0306465795
ISBN-13: 9780306465796

This book looks at the role of proteases, which are enzymes that digest proteins, and the various roles that proteases play in the development of neurodegenerative diseases such as Alzheimer’s disease, ALS, epilepsy, multiple sclerosis, as well as numerous other neuromuscular diseases.

Author: Robert D. E. Sewell
Publisher: CRC Press
Keywords: strategies, enzyme, inhibitors, series, therapeutic, mechanisms, misfolding, neurodegenerative, diseases, protein
Number of Pages: 592
Published: 2007-12-03
List price: $179.95
ISBN-10: 0849373107
ISBN-13: 9780849373107

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein

Authors:Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan
Publisher: Humana Press
Keywords: contemporary, neuroscience, disorders, neurodegenerative, inhibitors, mitochondrial
Number of Pages: 360
Published: 1999-10-01
List price: $165.00
ISBN-10: 089603805X
ISBN-13: 9780896038059

Respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers-many pioneers in the field-detail the symptomology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The emphasis on 3-NP and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington’s disease demonstrate that mitochondrial inhibitors play an important role in the

Authors:Judit Ovádi, Ferenc Orosz,
Publisher: Springer
Keywords: focus, structural, biology, diseases, neurodegenerative, folding, misfolding, protein
Number of Pages: 288
Published: 2009-01-14
List price: $129.00
ISBN-10: 1402094337
ISBN-13: 9781402094330

The worldwide increasing age of populations brought the neurodegenerative diseases into the focus of interest. A number of the diverse human neurodegenerative diseases are now recognized as conformational diseases frequently caused by aggregations of unfolded or misfolded proteins. Knowledge on the intrinsically unstructured proteins, a new family of gene products as well as on the misfolded proteins produced by genetic mutation or environmental effects has been extensively accumulated in the past years. These proteins frequently cause proteolytic stress and/ or enter into aberrant, non-physio

Authors:Peter H. St.George-Hyslop, William C. Mobley,
Publisher: Springer
Keywords: perspectives, alzheimer, disease, research, disorders, traffic, neurodegenerative, intracellular
Number of Pages: 198
Published: 2008-12-18
List price: $159.00
ISBN-10: 3540879404
ISBN-13: 9783540879404

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an i

Authors:J. Cummings, J. Hardy, M. Poncet, Yves Christe,
Publisher: Springer
Keywords: research, perspectives, alzheimer, disease, diseases, neurodegenerative, proteotype, phenotype, relationships, genotype
Number of Pages: 166
Published: 2005-05-31
List price: $139.00
ISBN-10: 3540248358
ISBN-13: 9783540248354

Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the current volume to produce a comprehensive overview of the role of protein misfolding in neurodegeneration. Links between genotype and protein characteristics and between proteotype and clinical phenomenology were discussed across diseases categories. Progress in understanding the role of abnormalities of protein metabolism may lead to the identificat