Author:
Publisher: Nova Biomedical Books
Keywords: research, methylation, dna, progress
Number of Pages: 256
Published: 2007-10
List price: unknow
ISBN-10: 1600217222
ISBN-13: 9781600217227

DNA methylation is a type of chemical modification of DNA that can be inherited without changing the DNA sequence. As such, it is part of the epigenetic code and is the most characterised epigenetic mechanism. DNA methylation involves the addition of a methyl group to DNA - for example, to the number 5 carbon of the cytosine pyrimidine ring. DNA methylation is probably universal in eukaryotes. In humans, approximately 1% of DNA bases undergo DNA methylation. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic s

Author: Manel Esteller
Publisher: CRC Press
Keywords: applications, approaches, methylation, dna
Number of Pages: 240
Published: 2004-07-26
List price: $184.95
ISBN-10: 084932050X
ISBN-13: 9780849320507

Understanding the complex roles of DNA methylation is currently an active field of research. DNA Methylation: Approaches and Applications presents the most current research on the impact of DNA methylation in human disease, particularly cancer. Written by leaders in the field, this state-of-art reference delineates the best techniques to use when addressing questions concerning the cytocine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book provides a balance between articles clarifying methodological details and mo

Authors:Ken I. Mills, Bernie H. Ramsahoye,
Publisher: Humana Pre
Keywords: molecular, biology, methods, protocols, methylation, dna
Number of Pages: 192
Published: 2002-03-01
List price: $89.95
ISBN-10: 0896036189
ISBN-13: 9780896036185

Univ. of Wales, Cardiff, UK. Covers new techniques currently available in the analysis of DNA methylation and methylases. For researchers.

Author: Moshe Szyf
Publisher: Springer
Keywords: intelligence, unit, medical, therapy, methylation, cancer, dna
Number of Pages: 239
Published: 2005-01-20
List price: $179.00
ISBN-10: 030647848X
ISBN-13: 9780306478482

This book provides a comprehensive analysis of implications of DNA methylation on cancer diagnosis and cancer therapy. This unique volume focuses on cancer therapy by thoroughly dissecting the basic principles of DNA methylation in cancer from molecular mechanisms to clinical trials. The chapters are written by leading experts in the field and are designed to provide the reader with the necessary background to evaluate critically the potential of DNA methylation in cancer therapy. Key features of this book include discussions of the following topics: The molecular machinery responsible for DN

Authors:J. P. Jost, H. P. Saluz,
Publisher: Birkhauser
Keywords: exs, experientia, supplementum, significance, biological, methylation, molecular, biology, dna
Number of Pages: 572
Published: 1993-01
List price: $232.00
ISBN-10: 0817627782
ISBN-13: 9780817627782

Authors:Walter Doerfler, Petra Boehm,
Publisher: Springer
Keywords: topics, microbiology, immunology, current, mechanisms, methylation, basic, dna
Number of Pages: 324
Published: 2006-02-10
List price: $129.00
ISBN-10: 3540291148
ISBN-13: 9783540291145

The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and funtion of the genome. Up to the present time, studies on the repetitive sequences, which comprise more than 90 per cent of the DNA sequences in the human or other genomes, have been neglected.

Authors:Sun-Chong Wang, Art Petronis,
Publisher: Chapman and Hall/CRC
Keywords: hall, amp, crc, biostatistics, series, chapman, analysis, microarrays, methylation, experimental, design, statistical, dna
Number of Pages: 256
Published: 2008-04-24
List price: $83.95
ISBN-10: 1420067273
ISBN-13: 9781420067279

Providing an interface between dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental Design and Statistical Analysis presents the statistical methods and tools to analyze high-throughput epigenomic data, in particular, DNA methylation microarray data. Since these microarrays share the same underlying principles as gene expression microarrays, many of the analyses in the text also apply to microarray-based gene expression and histone modification (ChIP-on-chip) studies. After introducing basic statistics, the book describes wet-bench technologies that