Authors:E.A. Moore, R. Janes,
Publisher: Royal Society of Chemistry
Keywords: bonding, ligand, metal
Number of Pages: 130
Published: 2004-01-23
List price: $89.95
ISBN-10: 0854049797
ISBN-13: 9780854049790
To appreciate the chemistry and physical properties of complexes of the transition series, an understanding of metal-ligand interactions applied to complexes of the d-block is needed. Metal Ligand Bonding aims to provide this through an accessible, detailed, non-mathematical approach.Initial chapters detail the crystal-field model, using it to describe the use of magnetic measurements to distinguish complexes with different electronic configurations and geometries. Subsequent chapters look at the molecular orbital theory of transition metal complexes using a pictorial approach. Bonding in
Author: M. Gerloch
Publisher: Cambridge University Press
Keywords: analysis, field, ligand, magnetism
Number of Pages: 607
Published: 1984-02-24
List price: $90.00
ISBN-10: 0521249392
ISBN-13: 9780521249393
In this book, originally published in 1983, a synthesis of old and new notions straddling the disciplines of physics and chemistry is described; and this provides a means of exploiting ligan-field properties of transition-metal and lathanide complexes leading to a quantified chemical insight into the individual metal-ligand interactions in these molecular species. Electronic spectroscopy and the ESR technique are well documented, but there has long been a need for a thorough description of magnetochemistry. A major section of this book therefore provides a details account of the physics and ch
Author: Irwing M. Klotz
Publisher: Wiley
Keywords: perplexed, guide, energetics, receptor, ligand
Number of Pages: 192
Published: 1997-03-14
List price: $99.95
ISBN-10: 0471176265
ISBN-13: 9780471176268
A foundation for quantitative perspectives and a framework for interpreting experimental observations. Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantitie
Author: Finet
Publisher: Elsevier Science
Keywords: tetrahedron, organic, chemistry, volume, compounds, coupling, reactions, heteroatomic, ligand
Number of Pages: 308
Published: 1998-10-21
List price: $59.95
ISBN-10: 0080427936
ISBN-13: 9780080427935
Paperback. The whole field of ligand coupling has only emerged in the last decade as a basis for new synthetic transformations. As Professor Finet shows in this comprehensive survey, the recent clarification of reaction mechanisms of ligand coupling process around heteroatom centres, now provides an understanding of these reactions which are certain to permit their application in organic synthesis, thereby achieving transformations which are quite difficult to achieve by other methods. This book provides in a thorough and scholarly way, a balanced coverage of the whole field.
Author: Didier Rognan
Publisher: Wiley-VCH
Keywords: principles, medicinal, chemistry, methods, receptors, design, protein, coupled, ligand
Number of Pages: 284
Published: 2006-03-31
List price: $210.00
ISBN-10: 3527312846
ISBN-13: 9783527312849
G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design. Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs. Essential reading for medicinal chemists and drug designers working wit
Authors:Kenneth M. Merz PhD, Dagmar Ringe PhD, Charles H. Re
Publisher: Cambridge University Press
Keywords: based, approaches, ligand, structure, design, drug
Number of Pages: 288
Published: 2010-05-31
List price: $150.00
ISBN-10: 0521887232
ISBN-13: 9780521887236
Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR, fragment-based drug design, free energy methods, docking and scoring, linear-scaling quantum calculations, QSAR, pharmacophore methods, computational ADME-Tox, and drug discovery case studies. A variety of authors from academic and commercial institutions all over the wo
Author: L. F. Lindoy
Publisher: Cambridge University Press
Keywords: chemistry, texts, biochemistry, cambridge, complexes, macrocyclic, ligand
Number of Pages: 280
Published: 1990-11-30
List price: $42.00
ISBN-10: 0521409853
ISBN-13: 9780521409858
The study of macrocyclic ligand systems represents a major activity impinging on a wide range of areas in chemistry and biochemistry. This book contains an overview of the macrocyclic ligand systems and discusses the structure and properties of macrocyclic systems; the synthesis of macrocycles; polyether crown and related systems; metal-ion and molecular recognition (host-guest chemistry); and kinetic, thermodynamic, and electrochemical aspects of these complexes. The author also covers the various categories of synthetic and naturally occuring macrocycles.
