Author: David A. Cheresh
Publisher: Academic Press
Keywords: enzymology, methods, volume, integrins
Number of Pages: 616
Published: 2007-09-10
List price: $182.00
ISBN-10: 0123739241
ISBN-13: 9780123739247

An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.

Author: Donald Gullberg
Publisher: Springer
Keywords: intelligence, unit, biology, molecular, integrins, domains
Number of Pages: 200
Published: 2003-07-31
List price: $189.00
ISBN-10: 0306478366
ISBN-13: 9780306478369

In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain. This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, th