Author: Alan Hall
Publisher: Oxford University Press, USA
Keywords: biology, molecular, frontiers, gtpases
Number of Pages: 360
Published: 2000-03-23
List price: $99.00
ISBN-10: 019963744X
ISBN-13: 9780199637447

GTPases are proteins that act as molecular switches to control biochemical pathways within a cell. Some GTPases tell a cell to divide and grow, while others cause a cell to move from one location to another. This book provides a complete guide to this area and should be essential reading for cell and molecular biologists, biochemists, and geneticists.

Author: Marc H. Symons
Publisher: Springer
Keywords: intelligence, unit, biology, molecular, gtpases, rho
Number of Pages: 248
Published: 2004-05-31
List price: $179.00
ISBN-10: 0306479923
ISBN-13: 9780306479922

Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins. This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the

Authors:Patrice Boquet, E. Lemichez,
Publisher: Springer
Keywords: topics, microbiology, immunology, current, gtpases, virulence, factors, rho, bacterial
Number of Pages: 198
Published: 2005-06-23
List price: $179.00
ISBN-10: 3540238654
ISBN-13: 9783540238652

Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The authors in this volume show a synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfil their virulence.

Authors:William E. Balch, Channing J. Der, Alan Hall,
Publisher: Academic Press
Keywords: membrane, dynamics, regulating, gtpases, enzymology, volume, methods
Number of Pages: 692
Published: 2005-12-27
List price: $182.00
ISBN-10: 0121828093
ISBN-13: 9780121828097

GTPases that regulate the myriad of membrane fission events that facilitate the assembly and disassembly of COPII (Sar1), COPI (ARF) and clathrin coats (dynamin) involved in exocytic and endocytic trafficking pathways and mitochrondrial organization remain a major challenge for future investigations to understand membrane architecture of eukaryotic cells. This volume of MIE provides a comprehensive set of articles describing the use and application of state-of-the-art methodologies to identify and characterize these GTPases and their rapidly expanding list of regulators and effectors. Methodo

Authors:William E. Balch, Channing J. Der, Alan Hall,
Publisher: Academic Pre
Keywords: membrane, targeting, fusion, regulating, gtpases, enzymology, vollume, methods
Number of Pages: 912
Published: 2005-12-27
List price: $182.00
ISBN-10: 0121828085
ISBN-13: 9780121828080

Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effe

Authors:William E. Balch, Channing J. Der, Alan Hall,
Publisher: Academic Press
Keywords: gtpases, ras, family, small, effectors, enzymology, volume, regulators, methods
Number of Pages: 780
Published: 2006-04-21
List price: $182.00
ISBN-10: 0121828123
ISBN-13: 9780121828127

The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continua

Authors:John N. Abelson, Melvin I. Simon, W. E. Balch, Channi
Publisher: Academic Press
Keywords: family, volume, methods, enzymology, ras, part, effectors, small, gtpases, regulators
Number of Pages: 492
Published: 2001-04-17
List price: $182.00
ISBN-10: 0121822338
ISBN-13: 9780121822330

The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today, truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325 and 329) cover all biochemical and b