Authors:James R. Lupski, Pawel T. Stankiewicz,
Publisher: Humana Press
Keywords: genomic, disease, disorders, basis
Number of Pages: 448
Published: 2006-04-15
List price: $159.00
ISBN-10: 1588295591
ISBN-13: 9781588295590

A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement,

Author: J.N. Housby
Publisher: Springer
Keywords: analysis, genomic, spectrometry, mass
Number of Pages: 149
Published: 2001-10-31
List price: $139.00
ISBN-10: 0792371739
ISBN-13: 9780792371731

The human genome project is set to revolutionise health care and medicine in the near future. The genetic make up of each individual gives clues as to the genetic factors that predispose one to a particular genetic disease. Single Nucleotide Polymorphisms (SNPs), single base changes in the nucleotide DNA sequence of individuals, are thought to be the main cause of genetic variation. By comparing patterns of SNP allele frequencies between disease affected and control populations, disease associated SNPs can be identified and potential disease gene(s) located. These types of study necess

Author: José Marín-García
Publisher: Academic Press
Keywords: cardiology, genomic, post
Number of Pages: 688
Published: 2007-03-12
List price: $175.00
ISBN-10: 0123736986
ISBN-13: 9780123736987

Recent advances in molecular and cellular biology have markedly changed our understanding of the heart, and this is having tremendous ramifications for the clinician. This unique reference offers a comprehensive and critical evaluation of this contribution in the field of cardiovascular molecular medicine providing the reader with a sense of new directions in which molecular medicine might be applied. It begins with a detailed primer that makes readily accessible recent molecular, genetic and cellular techniques. Rounding out the coverage of this exciting field are critical and comprenhesive d

Authors:R. Ohlsson, K. Hall, M. Ritzen,
Publisher: Cambridge University Press
Keywords: consequences, causes, imprinting, genomic
Number of Pages: 374
Published: 1995-01-15
List price: $150.00
ISBN-10: 0521472431
ISBN-13: 9780521472432

Genomic imprinting results in the preferential expression of one gene, depending on the parent of origin, and it is associated with several disease syndromes in humans. This book covers a wealth of research material on chromatin structure, epigenetics, clinical genetics, developmental biology, cancer, hypotheses of evolution, and the molecular basis of the imprinting process, which will help explain not only the mechanisms of genomic imprinting, but also its biological and medical consequences.

Author: Julien L. Van Lancker
Publisher: Jones & Bartlett Publishers
Keywords: cancer, integrity, genomic, apoptosis
Number of Pages: 422
Published: 2005-12-12
List price: $165.95
ISBN-10: 0763745413
ISBN-13: 9780763745417

Harmonious survival of the entire organism depends on the rigorous preservation of the controls that regulate the balance between the cell’s replication and apoptosis. This balance depends largely, although not exclusively, on the integrity of the genome. Cancer is a flagrant illustration of the danger of imbalance between cell proliferation and cell death. As cells replicate unfettered by normal controls, they invade the surrounding healthy population of cells, and they colonize distant organs. Van Lancker’s book introduces readers to the molecules involved in apoptosis and genomic integ

Author: Ivan Yu Torshin
Publisher: Nova Biomedical Books
Keywords: genomic, era, post, bioinformatics, medicine, physiology
Number of Pages: 302
Published: 2007-10-29
List price: $120.00
ISBN-10: 1600217524
ISBN-13: 9781600217524

Several years have passed since the sequencing of the human genome and what might be called ’the post-genomic era’ has begun. Of course, there are many different genomes and the term ’post-genomic’ does not necessarily imply the human genome. However, it is the data encoded in the human genome that hold the promise to be of practical importance in a wide range of biomedical applications. The sequencing and preliminary annotations of the human genome provided an incredible amount of the raw, largely unprocessed information. Coupled with the millions of publications on hu

Author: Ivan Yu Torshin
Publisher: Nova Science Publishers
Keywords: role, biophysics, era, genomic, post, bioinformatics
Number of Pages: 255
Published: 2007-01
List price: $120.00
ISBN-10: 1600210481
ISBN-13: 9781600210488

Biomedicine is one of the most important fields for the prospective applications of the information from human genome studies. However, there are many ’white spots’ in the present-day understanding of the biomedical implications of this information. Given that at least half of the proteins in the established sequence of the human genome have no annotation whatsoever and that the sequence similarity searches are not likely to produce any, definite research strategies to analyse the functions of these unknown proteins as well as other enigmatic aspects of the human genome are being e