Author: LASTNovartis Foundation
Publisher: Wiley
Keywords: novartis, foundation, symposium, symposia, syndrome, function, cardiac, potassium, channel, structure, herg
Number of Pages: 308
Published: 2005-04-08
List price: $179.95
ISBN-10: 0470021403
ISBN-13: 9780470021408

This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.  It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.  Better understanding of the role of th

Author: Greg Bear
Publisher: Eos
Keywords: foundation, trilogy, series, second, chaos
Number of Pages: 416
Published: 1999-05-01
List price: $7.99
ISBN-10: 0061056405
ISBN-13: 9780061056406

Isaac Asimov’s renowned Foundation Trilogy pioneered many of the familiar themes of modern science fiction and shaped many of its best writers. With the permission and blessing of the Asimov estate, the epic saga left unfinished by the Grand Master himself now continues with this second masterful volume. With Hari Seldon on trial for treason, the Galactic Empire’s long-anticipated migration to Star’s End is about to begin. But the mission’s brilliant robot leader, R. Daneel Olivaw, has discovered a potential enemy far deadlier--and closer--than he ever imagined. One of

Author: Novartis Foundation
Publisher: Wiley
Keywords: novartis, foundation, symposia, symposium, reactions, genomic, control, immune, decoding
Number of Pages: 232
Published: 2007-05-04
List price: $179.95
ISBN-10: 047002755X
ISBN-13: 9780470027554

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections.  The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. S

Author: Novartis Foundation
Publisher: Wiley
Keywords: novartis, foundation, symposia, symposium, chaperones, extracellular, molecular, biology
Number of Pages: 248
Published: 2008-05-20
List price: $184.95
ISBN-10: 0470723335
ISBN-13: 9780470723333

The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses.Since the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of mole

Author: Novartis Foundation
Publisher: Wiley
Keywords: novartis, foundation, symposia, symposium, disease, organization, development, nuclear
Number of Pages: 300
Published: 2005-03-14
List price: $184.95
ISBN-10: 0470093730
ISBN-13: 9780470093733

This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include:How nuclear structure and location within a nucleus affect gene expressionChromatin organization and cell differentiationThe nature of the interactions between the nuclear envelope and the cytoskeletonThe extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such

Author: Novartis Foundation
Publisher: Wiley
Keywords: foundation, new, novartis, symposia, symposium, therapies, insights, sepsis
Number of Pages: 302
Published: 2007-03-27
List price: $184.95
ISBN-10: 0470027983
ISBN-13: 9780470027981

Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. Addresses the frequent, but under-recognised

Author: LASTNovartis Foundation
Publisher: Wiley
Keywords: foundation, symposia, novartis, ageing, facets, endocrine
Number of Pages: 298
Published: 2002-02-28
List price: $179.95
ISBN-10: 0471486361
ISBN-13: 9780471486367

Social and medical developments have recently led to a dramatic increase in life expectancy. This has inspired the study of organismic changes associated with healthy ageing, in particular the erosion of homeostatic capabilities in multiple endocrine systems. This book reviews advances in the understanding of endocrine facets of ageing. It considers the relative magnitudes and time courses of different endocrine adaptations in the ageing human and experimental animal, addressing the influence of external factors on the rates of progression of endocrine sequelae in ageing, the mechanisms that