Authors:William E. Balch, Channing J. Der, Alan Hall,
Publisher: Academic Press
Keywords: gtpases, ras, family, small, effectors, enzymology, volume, regulators, methods
Number of Pages: 780
Published: 2006-04-21
List price: $182.00
ISBN-10: 0121828123
ISBN-13: 9780121828127

The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continua

Authors:John N. Abelson, Melvin I. Simon, W. E. Balch, Channi
Publisher: Academic Press
Keywords: family, volume, methods, enzymology, ras, part, effectors, small, gtpases, regulators
Number of Pages: 492
Published: 2001-04-17
List price: $182.00
ISBN-10: 0121822338
ISBN-13: 9780121822330

The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today, truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325 and 329) cover all biochemical and b