Authors:Weiming Xia, Huaxi Xu,
Publisher: CRC Press
Keywords: approach, practical, protein, precursor, amyloid
Number of Pages: 240
Published: 2004-12-16
List price: $184.95
ISBN-10: 0849322456
ISBN-13: 9780849322457

In the search for an effective treatment for Alzheimer’s disease, APP is a unique model protein that illustrates the wide array of basic and sophisticated characterization techniques available. Exploring a variety of biological techniques to clarify the structure and function of this transmembrane protein, this text presents each method with detailed, step-by-step protocols to achieve reproducible results and provide a framework for studying other membrane proteins.

Author: Einar M. Sigurdsson
Publisher: Humana Press
Keywords: biology, molecular, methods, proteins, amyloid
Number of Pages: 408
Published: 2004-12-28
List price: $134.00
ISBN-10: 1588293378
ISBN-13: 9781588293374

A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for d

Authors:Gilles Grateau, Robert A. Kyle, Martha Skinner,
Publisher: CRC Press
Keywords: amyloidosis, amyloid
Number of Pages: 576
Published: 2004-11-29
List price: $219.95
ISBN-10: 0849335345
ISBN-13: 9780849335341

This authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, including organ transplants and drug therapies; results from extensive clinical studies; and epidemiology. This is a valuable resource for clinicians who care for patients with systemic and localized forms of amyloidosis, and for researchers in biochemis

Authors:Ronald Wetzel, Indu Kheterpal,
Publisher: Academic Press
Keywords: volume, methods, enzymology, part, aggregates, prions, protein, amyloid
Number of Pages: 430
Published: 2006-10-20
List price: $182.00
ISBN-10: 0121828174
ISBN-13: 9780121828172

The ability of polypeptides to form alternatively folded, polymeric structures such as amyloids and related aggregates is being increasingly recognized as a major new frontier in protein research. This new volume of Methods in Enzymology along with Part C (volume 413) on Amyloid, Prions and other Protein Aggregates continue in the tradition of the first volume (309) in containing detailed protocols and methodological insights, provided by leaders in the field, into the latest methods for investigating the structures, mechanisms of formation, and biological activities of this important class of

Author: Ana Martinez
Publisher: Royal Society of Chemistry
Keywords: glucose, protein, metabolism, rsc, discovery, drug, tau, amyloid, targets, drugs, alzheimer, disease, beta, volume, emerging
Number of Pages: 317
Published: 2010-06-10
List price: $249.00
ISBN-10: 1849730636
ISBN-13: 9781849730631

Alzheimer’s disease is the most prevalent neurodegenerative disorder in the elderly. A recent study from the Bloomberg School of Public Health recently estimated that over 26 million people were living with the disease in 2006 and that the global prevalence of the disease will grow to 106 million by 2050. By that time, 43 per cent of those living with the disease will need high-level care, equivalent to that of a nursing home. However, even if modest advances in preventing or delaying the disease’s progression were made, it could have a huge impact on global public health. Accordin