Author: Guy Herve
Publisher: CRC Press
Keywords: enzymes, allosteric
Number of Pages: 269
Published: 1989-06-30
List price: $404.95
ISBN-10: 0849368545
ISBN-13: 9780849368547

This book compiles detailed information concerning a dozen of the best known allosteric enzymes, and so allows the comparison of their regulatory mechanisms and the confrontation of these mechanisms with the theoretical models. Stimulating and unexpected ideas emerge from these comparisons and emphasize the importance of developing various methods of investigation such as crystallography, X-ray solution scattering, and the study of fast movements in proteins and site-directed mutagenesis. This book is addressed to students and researchers interested in structure-function relationship in prote

Author: Thomas Traut
Publisher: Springer
Keywords: enzymes, allosteric, regulatory
Number of Pages: 250
Published: 2007-11-07
List price: $169.00
ISBN-10: 0387728880
ISBN-13: 9780387728889

All enzymes are remarkable since they have the ability to increase the rate of a chemical reaction, often by more than a billion-fold. Allosteric enzymes are even more amazing because the have the additional ability to change their rate in response to cellular activators or inhibitors. This enables them to control the pathway in which they are the regulatory enzyme. Since the effector molecules represent the current status of the cell for a given metabolic pathway, this results in very responsive and balanced metabolic states, and makes it possible for cells and organisms to be appropriately d

Authors:Michael G. Palfreyman, Ian J. Reynolds, Phil Skolnic
Publisher: CRC Press
Keywords: handbooks, pharmacology, toxicology, receptors, glutamate, allosteric, control, direct
Number of Pages: 192
Published: 1994-08-16
List price: $269.95
ISBN-10: 0849383072
ISBN-13: 9780849383076

Direct and Allosteric Control of Glutamate Receptors describes in detail recent research that has demonstrated that glutamate receptors are subject to numerous modulatory controls. Significant new insights into the physiology and pathophysiology of the nervous system have been obtained by these discoveries. The sites on the receptor proteins where modulation occurs have provided a platform of opportunities for medicinal chemists to design new therapeutic modalities. These new drugs will be of major significance in treating diseases (such as stroke, Alzheimer’s, epilepsy, Parkinson’