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Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology

Authors:Bernard Testa, Joachim M. Mayer
Publisher: Wiley-VCH
Keywords: biochemistry, enzymology, chemistry, metabolism, drug, prodrug, hydrolysis
Number of Pages: 800
Published: 2003-09-01
List price: $275.00
ISBN-10: 390639025X
ISBN-13: 9783906390253

Book Description:

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically.

Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.


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