Author: Hugo Kubinyi
Publisher: Vch Pub
Keywords: principles, medicinal, chemistry, methods, approaches, hansch, analysis, related, qsar
Number of Pages: 240
Published: 1993-10
List price: $215.00
ISBN-10: 352730035X
ISBN-13: 9783527300358

Quantitative Structure Activity Relationships (QSAR) are fundamental to all modern drug research, as carried out worldwide in industrial and other research laboratories. This volume covers the subject and can be used as a source of information or an advanced textbook. Topics range from the pioneering work of Hansch to modern applications of QSAR, including recent computer-aided achievements.

Author: Hugo Kubinyi
Publisher: Springer
Keywords: quantitative, dimensional, structure, activity, relationships, three, applications, design, drug, volume, theory, methods, qsar
Number of Pages: 788
Published: 1993-12-31
List price: $629.00
ISBN-10: 9072199146
ISBN-13: 9789072199140

Progress in medicinal chemistry and in drug design depends on our ability to understand the interactions of drugs with their biological targets. Classical QSAR studies describe biological activity in terms of physicochemical properties of substituents in certain positions of the drug molecules. The purpose of this book is twofold: On the one hand, both the novice and the experienced user will be introduced to the theory and application of 3D QSAR analyses, and on the other, a comprehensive overview of the scope and limitations of these methods is given. The detailed discussion of the present s

Authors:Hugo Kubinyi, Gerhard M?ller,
Publisher: Wiley-VCH
Keywords: chemistry, medicinal, methods, principles, perspective, drug, chemogenomics, discovery
Number of Pages: 487
Published: 2004-10-08
List price: $250.00
ISBN-10: 352730987X
ISBN-13: 9783527309870

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and from leading pharmaceutical companies, this book is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discov

Authors:Hugo Kubinyi, Gerd Folkers, Yvonne C. Martin,
Publisher: Kluwer/ESCOM
Keywords: volume, structure, quantitative, activity, relationships, dimensional, advances, drug, design, recent, qsar, three
Number of Pages: 352
Published: 1998-12-31
List price: $279.00
ISBN-10: 0792347919
ISBN-13: 9780792347910

Volumes 2 and 3 of the 3D QSAR in Drug Design series aim to review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the highly successful first volume about four years ago. Volume 2 (Ligand-Protein Interactions and Molecular Similarity) divides into three sections dealing with Ligand-Protein Interactions, Quantum Chemical Models and Molecular Dynamics Simulations, and Pharmacophore Modelling and Molecular Similarity, respectively. Volume 3 (Recent Advances) is also divided into three sections, namely 3D QSAR Methodology: CoMFA and Related Approa

Authors:Hugo Kubinyi, Gerd Folkers, Yvonne C. Martin,
Publisher: Springer
Keywords: dimensional, three, quantitative, structure, relationships, activity, similarity, molecular, design, drug, volume, ligand, interactions, protein, qsar
Number of Pages: 432
Published: 1998-04-30
List price: $259.00
ISBN-10: 0792347900
ISBN-13: 9780792347903

Volumes 2 and 3 of the 3D QSAR in Drug Design series aim to review the progress being made in CoMFA and other 3D QSAR approaches since the publication of the highly successful first volume about four years ago. Volume 2 (Ligand-Protein Interactions and Molecular Similarity) divides into three sections dealing with Ligand-Protein Interactions, Quantum Chemical Models and Molecular Dynamics Simulations, and Pharmacophore Modelling and Molecular Similarity, respectively. Volume 3 (Recent Advances) is also divided into three sections, namely 3D QSAR Methodology: CoMFA and Related Approa

Authors:Yvonne Fortin, Hugo Van Hassel, Hugo Van Hassel,
Publisher: Ios Pr Inc
Keywords: administrative, sciences, monographs, vol, institute, international, new, public, management, contracting
Number of Pages: 296
Published: 2000-01
List price: $97.00
ISBN-10: 158603037X
ISBN-13: 9781586030377

This book focuses on internal management contracts and includes contributions analyzing the economic, political, legal, historical and cultural context in which such contracts are being implemented. It particularity concentrated on devising an approach that is international, pluridisciplinary and truly comparative. Moreover, it broaches those (sometimes) neglected sectors and issues, at least at the international level, such as the role of trade unions, professional associations, local authorities, as well as relationships among stakeholders and trusts. Although based on European countries, in

Authors:Hugo Delgado-Granados, Hugo Delgado-Granados, Gerard
Publisher: Geological Society of America
Keywords: america, special, papers, society, geological, tectonics, volcanism, mexico, cenozoic
Number of Pages: 275
Published: 1999-06
List price: $12.00
ISBN-10: 0813723345
ISBN-13: 9780813723341