Author: CIBA Foundation SymposiumCIBA Foundation Symposiu
Publisher: Wiley
Keywords: symposium, suppression, tumour, analysis, genetic
Number of Pages: 268
Published: 1989-03-29
List price: $175.00
ISBN-10: 0471922994
ISBN-13: 9780471922995

Comprises the proceedings of a symposium held at the Ciba Foundation, London, February 1988. Contains the latest research results on the inverse relationship between cell proliferation and differentiation and the nature of the genes involved. Included are the studies of cell fusion experiments, the introduction of single chromosomes into malignant cells, and the transfection of individual genes. Also reports on the role of certain oncogenes in normal development, lineage commitment, and tumorigenesis.

Author: CIBA Foundation Symposium
Publisher: Wiley
Keywords: response, symposium, allergic, cells, mast, ige
Number of Pages: 292
Published: 1990-01-26
List price: $175.00
ISBN-10: 0471923095
ISBN-13: 9780471923091

IgE, Mast Cells and the Allergic Response Chairman: H. Metzger 1989 Allergy, like autoimmunity, is an aberration of the immune reponse. It is still far from clear why certain individuals produce antibodies to harmless stimuli which elicit minor or no responses in other people, or why these antibodies should be chiefly of the IgE class. What is clear is that the prevalence of allergic disorders is high and is increasing: it has been estimated that 120f the world’s population suffers, or will suffer, from IgE-mediated allergies. This symposium reviews and debates recent basic research into IgE

Author: CIBA Foundation Symposium
Publisher: Wiley
Keywords: symposium, oscillations, gradients, waves, calcium
Number of Pages: 302
Published: 1995-06-28
List price: $175.00
ISBN-10: 0471952346
ISBN-13: 9780471952343

Calcium Waves, Gradients and Oscillations Chairman: Michael J. Berridge 1995 Standing free gradients are widespread in living systems and changes in intracellular free Ca2+ concentration, [Ca2+]i, are involved in controlling the responses of cells to many stimuli. Imaging techniques have revealed complex patterns of Ca2+ distribution arising spontaneously or after stimulation of cells by hormones or neurotransmitters. In many cells, Ca2+- mobilizing agonists stimulate oscillations in [Ca2+]i, with the frequency of the concentration rises (‘spikes’) depending on the agonist concentration an

Author: CIBA Foundation Symposium
Publisher: Wiley
Keywords: symposium, agents, therapeutic, oligonucleotides
Number of Pages: 260
Published: 1997-10-14
List price: $175.00
ISBN-10: 0471972797
ISBN-13: 9780471972792

The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book d

Author: CIBA Foundation Symposium
Publisher: Wiley
Keywords: foundation, symposia, novartis, system, neuromuscular, plasticity
Number of Pages: 284
Published: 1988-10-12
List price: $175.00
ISBN-10: 0471919020
ISBN-13: 9780471919025

Presents new information on the mutual interaction of skeletal muscle fibers and motoneurons at all levels, from the physiological to the molecular. Covers genetic, physiological, and hormonal factors affecting skeletal muscle development, control of acetylcholine receptor gene expression, selection and organization of motoneurons, and remodelling and refinement of synaptic inputs under the influence of muscle-derived growth factors. Also discusses the plasticity of the neuromuscular system during regeneration after injury, and in the modification of muscle properties and movement patterns in

Author: CIBA Foundation Symposium
Publisher: Wiley
Keywords: foundation, symposia, novartis, viruses, diarrhoea, novel
Number of Pages: 280
Published: 1987-04-22
List price: $175.00
ISBN-10: 0471910945
ISBN-13: 9780471910947

Until recently a neglected disease syndrome, diarrhea is responsible for many millions of infant deaths in developing countries. The result of a 1987 symposium, this volume reflects advances in the aetiology of diarrhea while addressing such puzzling problems as the difficulty of growing viruses in a controlled setting. The volume is deliberately restricted to so-called ``novel’’ diarrhea viruses and is not concerned with ``classical’’ rotaviruses, which have formed the basis of previous symposia. Articles concentrate on: atypical rotaviruses; the enteric adenoviruses;

Author: CIBA Foundation Symposium
Publisher: Wiley
Keywords: novartis, foundation, symposia, biology, chemistry, guest, molecular, interactions, host
Number of Pages: 288
Published: 1991-05
List price: $178.95
ISBN-10: 0471929581
ISBN-13: 9780471929581

Host-Guest Molecular Interactions: From Chemistry to Biology Chairman: I.O. Sutherland 1991 Host—guest molecular interactions lead to the formation of molecular assemblies containing two or more species. It has long been recognized that such ‘supramolecular’ association is of fundamental importance in biological processes, but it is only recently that chemists have begun to design and synthesize novel host molecules. The field is relatively new, but exciting applications are already emerging, for example in the development of molecular sensors, of new chromogenic reagents and of reagents